Northern Biomolecular Services
Northern Biomolecular Services
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OUR CAPABILITIES

Custom Primers and Probes

Custom Primers and Probes

Custom Primers and Probes

Personalized design of primers and probe to target DNA/RNA in the background of host genomic DNA/RNA

Personalized design of primers and probe to target DNA and RNA in the background of host genomic DNA/RNA  

Nucleic Acid Extraction

Custom Primers and Probes

Custom Primers and Probes

Purification of DNA and RNA

 Purification of DNA and RNA from frozen tissues, blood, cultured cells, swabs, and a range of biofluids  

DNA/RNA Assessment

Custom Primers and Probes

Assay Development and Validation

Quantification, quality assessment, and stability analysis of DNA and RNA samples

Quantification, quality assessment, and stability analysis of DNA and RNA samples  

Assay Development and Validation

Absolute and Relative Quantification

Assay Development and Validation

Robust procedures implemented for assay development and validation/qualification

Robust procedures implemented for assay development and validation/qualification to satisfy GLP and non-GLP needs  

Absolute and Relative Quantification

Absolute and Relative Quantification

Absolute and Relative Quantification

Quantification of DNA by qPCR and RNA by both one-step RT-qPCR and two-step RT-qPCR

Quantification of DNA by qPCR and RNA by both one-step RT-qPCR and two-step RT-qPCR  

On-time GLP-Compliant Reporting

Absolute and Relative Quantification

Absolute and Relative Quantification

comprehensive GLP-compliant data reporting

On-time, comprehensive GLP-compliant data reporting tailored to our sponsor’s needs  

CURRENT ASSAYS

Biodistribution and persistence of gene and cell therapy products

Biodistribution and persistence of oligonucleotides and RNA silencing products

Vector-derived transgene and endogenous gene expression by RT-qPCR

Vector-derived transgene and endogenous gene expression by RT-qPCR

Biodistribution and persistence of oligonucleotides and RNA silencing products

Vector-derived transgene and endogenous gene expression by RT-qPCR

 (Absolute and relative quantification) 

Biodistribution and persistence of oligonucleotides and RNA silencing products

Biodistribution and persistence of oligonucleotides and RNA silencing products

Biodistribution and persistence of oligonucleotides and RNA silencing products

Formulation analysis of viral and non-viral test articles

Formulation analysis of viral and non-viral test articles

Biodistribution and persistence of oligonucleotides and RNA silencing products

Quantification of viral vector shedding (preclinical)

Formulation analysis of viral and non-viral test articles

Quantification of viral vector shedding (preclinical)

INSTRUMENTATION

ThermoFisher's QuantStudio 7 Flex

ThermoFisher's QuantStudio 7 Flex

ThermoFisher's QuantStudio 7 Flex

ThemoFisher QuantStuido 7 real-time PCR instrument capable of high-throughput automation

 Technologically advanced real-time PCR instrument capable of high-throughput automation with the additional benefit of an interchangeable block.  

QIAGEN's QIAsymphony

ThermoFisher's QuantStudio 7 Flex

ThermoFisher's QuantStudio 7 Flex

QIAGEN's QIAsymphony State-of-the-art system for automated DNA purification allowing for efficient p

State-of-the-art system for automated DNA purification allowing for efficient processing of collected samples while maintaining high quality.   

Nanodrop 8000 Spectrophotometer

Precellys 24 Tissue Homogenizer

Precellys 24 Tissue Homogenizer

Utilizing an 8-channel spectrophotometer, nucleic acid concentrations are efficiently measured and quality is assessed  following purification procedures.  

Precellys 24 Tissue Homogenizer

Precellys 24 Tissue Homogenizer

Precellys 24 Tissue Homogenizer

High throughput bead mill homogenizer using multidirectional motion for homogenization of tissues prior to purification procedures.  

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